Gal 6:18; 2 Tm 4:22And with your spirit.We make this response five times during the Mass: after the priest’s greeting at the beginning of Mass, right before the Gospel is read, at the beginning of the Eucharistic Prayer, at the Sign of Peace, and right before the final blessing.
The response has changed from “And also with you” to “And with your spirit,” a change that brings the English text in line not only with the Latin, but also with the Spanish, French, Italian, and German texts.
What does “your spirit” mean here? St. John Chrysostom (A.D. 347-407), bishop of Constantinople and a Church Father, spoke about the response “and with your spirit” in a sermon at a Divine Liturgy celebrated by another bishop:
If the Holy Spirit were not in [Bishop Flavian], you would not [...] have cried out with one accord, “And with your spirit.” Thus you cry out to him, not only when he ascends his throne, when he speaks to you and prays for you, but also when he stands at this holy altar to offer the awesome Sacrifice. He does not touch that which lies on the altar before wishing you the grace of our Lord and before you have replied to him: “And with your spirit.” By this cry you are reminded that he who stands at the altar does nothing, and that the gifts that rest thereon are not the merits of man, but that the grace of the Holy Spirit is present and, descending on all, accomplishes this mysterious Sacrifice. We see indeed a man, but God it is Who acts through him. Nothing human takes place at this holy altar. (First Homily for the Feast of Pentecost, 4)According to St. John Chrysostom, the response to the bishop (or priest) emphasizes the presence and action of the Holy Spirit in him.